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A meta-analysis of such expression profiles was performed to derive novel conclusions and to validate the known findings. [129] Meta-analysis of whole genome sequencing studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes.
For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0.05. In statistics, Fisher's method, [1] [2] also known as Fisher's combined probability test, is a technique for data fusion or "meta-analysis" (analysis of analyses).
Meta-regression. Meta-regression is defined to be a meta-analysis that uses regression analysis to combine, compare, and synthesize research findings from multiple studies while adjusting for the effects of available covariates on a response variable. A meta-regression analysis aims to reconcile conflicting studies or corroborate consistent ...
An example forest plot of five odds ratios (squares, proportional to weights used in meta-analysis), with the summary measure (centre line of diamond) and associated confidence intervals (lateral tips of diamond), and solid vertical line of no effect. Names of (fictional) studies are shown on the left, odds ratios and confidence intervals on ...
Metanarrative. In social theory, a metanarrative (also master narrative, or meta-narrative and grand narrative; French: métarécit or grand récit) is an overarching narrative about smaller historical narratives, which offers a society legitimation through the anticipated completion of a (as yet unrealized) master idea.
A systematic review and network meta-analysis published in The BMJ compared the options for oral monotherapy treatment of migraine attacks, looking at data from 137 randomized controlled trials ...
The combination of data from a meta-analysis can sometimes be visualised. One method uses a forest plot (also called a blobbogram). [35] In an intervention effect review, the diamond in the 'forest plot' represents the combined results of all the data included. [35] An example of a 'forest plot' is the Cochrane Collaboration logo. [35]
The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. [3] PRISMA has mainly focused on systematic reviews and meta-analysis of randomized trials, but it can also be used as a basis for reporting reviews of other types of research (e.g., diagnostic studies, observational studies).
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