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The National Center for Biotechnology Information ( NCBI) [1] [2] is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States. The NCBI is located in Bethesda, Maryland, and was founded in 1988 through legislation sponsored by US Congressman Claude Pepper .
The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations. It is produced and maintained by the National Center for Biotechnology Information (NCBI; a part of the National Institutes of Health in the United States) as part of the International Nucleotide Sequence Database Collaboration (INSDC).
The Reference Sequence ( RefSeq) database [1] is an open access, annotated and curated collection of publicly available nucleotide sequences ( DNA, RNA) and their protein products. RefSeq was introduced in 2000. [2] [3] This database is built by National Center for Biotechnology Information (NCBI), and, unlike GenBank, provides only a single ...
The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of a population of a given species. The genotype, along with environmental and developmental factors, ultimately ...
Gene nomenclature. Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms. It is also closely associated with protein nomenclature, as genes and the proteins they code for usually have similar nomenclature.
Gene Expression Omnibus ( GEO) is a database for gene expression profiling and RNA methylation profiling managed by the National Center for Biotechnology Information (NCBI). [1] These high-throughput screening genomics data are derived from microarray or RNA-Seq experimental data. [2] These data need to conform to the minimum information about ...
dbSNP. The Single Nucleotide Polymorphism Database [1] ( dbSNP) is a free public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI). Although the name of the database implies ...
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. [1] It consists of nucleotide sequences of DNA (or RNA in RNA viruses ). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA ), and often a substantial fraction of junk DNA with no ...