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The Reed–Muench method is a simple method for determining 50% endpoints in experimental biology, [1] that is, the concentration of a test substance that produces an effect of interest in half of the test units. Examples include LD50 (the median lethal dose of a toxin or pathogen), EC50 and IC50 (half maximal effective or inhibitory ...
The values of the sums converge as the subintervals halve from top-left to bottom-right. In mathematics, a Riemann sum is a certain kind of approximation of an integral by a finite sum. It is named after nineteenth century German mathematician Bernhard Riemann.
Clinical endpoint. Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials. The term may also refer to any disease or sign that strongly motivates withdrawal of an individual or entity from the trial, then ...
Equivalence point. The equivalence point, or stoichiometric point, of a chemical reaction is the point at which chemically equivalent quantities of reactants have been mixed. For an acid-base reaction the equivalence point is where the moles of acid and the moles of base would neutralize each other according to the chemical reaction.
An interval is a subset of the real numbers that contains all real numbers lying between any two numbers of the subset. The endpoints of an interval are its supremum, and its infimum, if they exist as real numbers. [1] If the infimum does not exist, one says often that the corresponding endpoint is Similarly, if the supremum does not exist, one ...
Relative permeability. In multiphase flow in porous media, the relative permeability of a phase is a dimensionless measure of the effective permeability of that phase. It is the ratio of the effective permeability of that phase to the absolute permeability. It can be viewed as an adaptation of Darcy's law to multiphase flow.
Hazard ratio. In survival analysis, the hazard ratio ( HR) is the ratio of the hazard rates corresponding to the conditions characterised by two distinct levels of a treatment variable of interest. For example, in a clinical study of a drug, the treated population may die at twice the rate per unit time [clarify] of the control population.
Simpson's 1/3 rule, also simply called Simpson's rule, is a method for numerical integration proposed by Thomas Simpson. It is based upon a quadratic interpolation and is the composite Simpson's 1/3 rule evaluated for . Simpson's 1/3 rule is as follows:
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